Publications
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RESEARCH HIGHLIGHT
· High-throughput experimental and computational analysis of pre-mRNA splicing regulation
· Post-transcriptional mis-regulation in diseases
· Molecular and biochemical analysis of pre-mRNA splicing and translational control
a. journal articles
(underlined are members of Lin's Lab)
1. Hung-Lun Chiang*, Yi-Ting Chen*, Jia-Ying Su*, Hsin-Nan Lin, Chen-Hsin Albert Yu, Yu-Jen Hung, Yun-Lin Wang, Yen-Tsung Huang, Chien-Ling Lin. 2022. Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing. Nature Structural & Molecular Bioigy. (*contributed equally) link
1. Hsiao-Jung Kao, Hung-Lun Chiang, Hsiao-Huei Chen, Pi-Chuang Fan, Yi-Fang Tu, Yen-Yin Chou, Wuh-Liang Hwu, Chien-Ling Lin, Pui-Yan Kwok and Ni-Chung Lee. 2020. De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome. Human Mutation 41:1775-1782. link
2. Allison J Taggart*, Chien-Ling Lin*, Barsha Shrestha, Claire Heintzelman, Seong Won Kim and William G Fairbrother. 2017. Large-scale Analysis of Branchpoint Usage across Species and Cell Lines. Genome Research 27:639-649. (*contributed equally) link
3. Yen-Tsung Huang, Su Chu, Eric B Loucks, Chien-Ling Lin, Charles B Eaton, Stephen L Buka and Karl T Kelsey. 2016. Epigenome-wide Profiling of DNA Methylation in Paired Samples of Adipose Tissue and Blood. Epigenetics 11:227236. link
4. Chien-Ling Lin*, Allison J Taggart*, Kian Huat Lim*, Kamil J Cygan, Luciana Ferraris, Robbert Creton, Yen-Tsung Huang, and William G Fairbrother. 2016. RNA structure replaces the need for U2AF2 in splicing. Genome Research 26:12-23. (*contributed equally) link
5. Yen-Tsung Huang, Thomas Hsu, Karl T. Kelsey and Chien-Ling Lin. 2015. Integrative analysis of micro-RNA, gene expression, and survival of glioblastoma multiforme. Genet Epidemiol. 39:134-143. link
6. Moris Nechama, Chien-Ling Lin and Joel D. Richter. 2013. An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol. 33: 48-58.
link
7. Chien-Ling Lin, Yen-Tsung Huang and Joel D. Richter. 2012. Transient CPEB Dimerization and Translational Control. RNA 18: 1050-1061. link
8. Chien-Ling Lin, Veronica Evans, Shihao Shen, Yi Xing and Joel D. Richter. 2010. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA 16: 338-348. link
9. Andrew C. Lin, Chin Lik Tan, Chien-Ling Lin, Laure Strochlic, Yi-Shuian Huang, Joel D. Richter and Christine E. Holt. 2009. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. Neural Development 4: 8.
10. Shiaw-Wei Tyan, Ming-Chi Tsai, Chien-Ling Lin, Yun-Li Ma and Eminy H. Y. Lee. 2008. Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. Journal of Neurochemistry 105: 820-832.
11. Yi-Shuian Huang*, Ming-Chung Kan*, Chien-Ling Lin and Joel D. Richter. 2006. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. EMBO Journal 25: 4865-4876. (*contributed equally)
b. review articles
· High-throughput experimental and computational analysis of pre-mRNA splicing regulation
· Post-transcriptional mis-regulation in diseases
· Molecular and biochemical analysis of pre-mRNA splicing and translational control
a. journal articles
(underlined are members of Lin's Lab)
1. Hung-Lun Chiang*, Yi-Ting Chen*, Jia-Ying Su*, Hsin-Nan Lin, Chen-Hsin Albert Yu, Yu-Jen Hung, Yun-Lin Wang, Yen-Tsung Huang, Chien-Ling Lin. 2022. Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing. Nature Structural & Molecular Bioigy. (*contributed equally) link
1. Hsiao-Jung Kao, Hung-Lun Chiang, Hsiao-Huei Chen, Pi-Chuang Fan, Yi-Fang Tu, Yen-Yin Chou, Wuh-Liang Hwu, Chien-Ling Lin, Pui-Yan Kwok and Ni-Chung Lee. 2020. De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome. Human Mutation 41:1775-1782. link
2. Allison J Taggart*, Chien-Ling Lin*, Barsha Shrestha, Claire Heintzelman, Seong Won Kim and William G Fairbrother. 2017. Large-scale Analysis of Branchpoint Usage across Species and Cell Lines. Genome Research 27:639-649. (*contributed equally) link
3. Yen-Tsung Huang, Su Chu, Eric B Loucks, Chien-Ling Lin, Charles B Eaton, Stephen L Buka and Karl T Kelsey. 2016. Epigenome-wide Profiling of DNA Methylation in Paired Samples of Adipose Tissue and Blood. Epigenetics 11:227236. link
4. Chien-Ling Lin*, Allison J Taggart*, Kian Huat Lim*, Kamil J Cygan, Luciana Ferraris, Robbert Creton, Yen-Tsung Huang, and William G Fairbrother. 2016. RNA structure replaces the need for U2AF2 in splicing. Genome Research 26:12-23. (*contributed equally) link
5. Yen-Tsung Huang, Thomas Hsu, Karl T. Kelsey and Chien-Ling Lin. 2015. Integrative analysis of micro-RNA, gene expression, and survival of glioblastoma multiforme. Genet Epidemiol. 39:134-143. link
6. Moris Nechama, Chien-Ling Lin and Joel D. Richter. 2013. An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol. 33: 48-58.
link
7. Chien-Ling Lin, Yen-Tsung Huang and Joel D. Richter. 2012. Transient CPEB Dimerization and Translational Control. RNA 18: 1050-1061. link
8. Chien-Ling Lin, Veronica Evans, Shihao Shen, Yi Xing and Joel D. Richter. 2010. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA 16: 338-348. link
9. Andrew C. Lin, Chin Lik Tan, Chien-Ling Lin, Laure Strochlic, Yi-Shuian Huang, Joel D. Richter and Christine E. Holt. 2009. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. Neural Development 4: 8.
10. Shiaw-Wei Tyan, Ming-Chi Tsai, Chien-Ling Lin, Yun-Li Ma and Eminy H. Y. Lee. 2008. Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. Journal of Neurochemistry 105: 820-832.
11. Yi-Shuian Huang*, Ming-Chung Kan*, Chien-Ling Lin and Joel D. Richter. 2006. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. EMBO Journal 25: 4865-4876. (*contributed equally)
b. review articles
- Rachel Soemedi, Kamil J. Cygan, Christy Rhine, David T. Glidden, Allison J. Taggart, Chien-Ling Lin, Alger M. Fredericks, William G. Fairbrother. 2017. The Effects of Structure on pre-mRNA Processing and Stability. Methods 125:36-44.
- Chien-Ling Lin, Allison J Taggart, William G Fairbrother. 2016. RNA Structure in Splicing: an Evolutionary Perspective. RNA Biol. 13:766-771. link
- Hung-Lun Chiang, Yi-Ting Chen, Yun-Lin Wang, Chia-Ying Su, Yen-Tsung Huang, Chien-Ling Lin. Systematic Characterization of branch site mutations perturbing RNA splicing. The 26th Annual Meeting of the RNA Society. Virtual. May 2021.
- Chien-Ling Lin, Fang-Yu Su, Shih-Wen Du, Yu-Ying Huang, Yi-Chieh Sung and Ren-In You. Response of RNA splicing in tyrosine kinase inhibitor-resistant leukemia. The 26th Annual Meeting of the RNA Society. Virtual. May 2021.
- Yi-Ting Chen, Hung-Lun Chiang, Yun-Lin Wang and Chien-Ling Lin. Systematic characterization of branchsite mutations perturbing RNA splicing. Bay Area RNA Club Meeting. Virtual. Dec. 2020.
- Yu-Chi Chang, Yun-Lin Wang, Wei-Ping Li, Yi-Hsuan Chiang, YoonSoon Kang, Yen-Ling Ko, Bing-Jen Chiang and Chien-Ling Lin. Massively parallel analysis on RNA stability and translation of disease-associated UTR variants. EMBO|EMBL Symposium: The Complex Life of RNA. Virtual. Oct. 2020.
- Yu-Chi Chang, Bing-Jen Chiang, Wei-Ping Li, Yun-Lin Wang and Chien-Ling Lin. Translation Efficiency is Affected by Disease-Associated SNPs in Untranslated Region. 2019 Multiomics and Precision Medicine Joint Conference, Tainan, Taiwan. Dec 2019.
- Wei-Ping Li, Yi-Hsuan Chiang, YoonSoon Kang, Yun-Lin Wang and Chien-Ling Lin. Systematic Analysis of the Effects of Disease-Associated Variants in UTRs on Translational Efficiency of mRNA. 2019 Multiomics and Precision Medicine Joint Conference, Tainan, Taiwan. Dec 2019.
- Ching-Ju Lin, Yun-Lin Wang and Chien-Ling Lin. Systematic Identification of Pathogenic Splicing Mutations of TSC1/2. 2019 Multiomics and Precision Medicine Joint Conference, Tainan, Taiwan. Dec 2019. (Second Place Poster Award)
- Yun-Lin Wang, YoonSoon Kang and Chien-Ling Lin. Systematic Analysis of the Effect of UTR Variants on RNA Stability. 2019 Multiomics and Precision Medicine Joint Conference, Tainan, Taiwan. Dec 2019.
- Hung-Lun Chiang, Jer-Yuan Wu, Yuan-Tsong Chen and Chien-Ling Lin. Aberrant Exon Skipping of CAMTA2 Is Induced by Branchpoint SNP. 2019 Multiomics and Precision Medicine Joint Conference, Tainan, Taiwan. Dec 2019.
- Yun-Lin Wang, YoonSoon Kang and Chien-Ling Lin. Systematic Analysis of the Effect of UTR Variants on RNA Stability. EMBO|EMBL Symposium: Multiomics to Mechanisms. Heidelberg, Germany. September 2019.
- Chien-Ling Lin. Large-Scale Analysis of Branchpoint Usage. RPAS-NTU Retreat. RNA Program in Academia Sinica. New Taipei City, Taiwan. Dec 2017.
- Chien-Ling Lin, Allison J Taggart and William G Fairbrother. The Second Life of Intron. Boston Taiwanese Biotechnology Symposium. Cambridge, Massachusetts. July 2016.
- Chien-Ling Lin, Allison J Taggart, Barsha Shrestha and William G Fairbrother. Profiling lariats in vivo reveals novel splicing mechanisms. Cold Spring Harbor Laboratory meeting on Eukaryotic mRNA Processing. Cold Spring Harbor, New York. August 2015.
- Chien-Ling Lin, Allison J Taggart, Barsha Shrestha and William G Fairbrother. Genome-wide Lariat profiling reveals the Structure and Function of Branched Intermediates of Splicing. Boston Taiwanese Biotechnology Symposium. Cambridge, Massachusetts. June 2015.
- Chien-Ling Lin, Kian-Huat Lin, Allison J Taggart, Luciana Ferraris and William G Fairbrother. An ancient class of structured intron demonstrates a widespread role for dinucleotide repeats in vertebrate gene expression. Boston Taiwanese Biotechnology Symposium. Cambridge, Massachusetts. June 2014.
- Chien-Ling Lin, Allison Taggart and William G Fairbrother. Profiling intermediates of gene expression in vivo: a novel application to study inherited RNA splicing defects. Center for Computational Molecular Biology Symposium on Modern Genetic Approaches to Inheritable Disease. Providence, Rhode Island. May 2014.
- Chien-Ling Lin, Kian-Huat Lin, Allison J Taggart, Luciana Ferraris and William G Fairbrother. A novel class of structured intron illustrates a function for expansions of simple repeats in vertebrate gene expression. Cold Spring Harbor Laboratory meeting on Eukaryotic mRNA Processing. Cold Spring Harbor, New York. August 2013.